Liposomal Estro Detox Ultra

NZD $115.00 (GST incl)

Why recommend an estrogen detox?
Increasing numbers of young girls, boys and men and women suffer from the consequences of a toxic food environment filled with sugar and fats that promote obesity, estrogen imbalance, and early puberty. Our industrial environment, filled with xenotoxic estrogens, disturbs normal hormonal cycles and stimulates premature development. Chemicals, stress, diet and ageing may all contribute to hormonal imbalance. With hormonal imbalance, blood circulation and cardiovascular health may also be affected.

Estro Detox may support & health with:

  • Mood balance
  • Anger
  • Nervous Tension
  • Irritability
  • Lack of energy
  • Emotional outbursts
  • Stress & Weepiness
  • Oily Skin and Hair
  •  Fluid balance
  • Healthy weight management

SUPPORT ESTROGEN BALANCE AND HARMFUL TOXIN DETOXIFICATION NATURALLY WITH ADVANCED LIPOSOMAL TECHNOLOGY:
The aim is to ensure healthy removal pathways are active. Estrogen balance requires keeping the liver and digestive tract functioning well. The liver metabolises estrogen, which passes into the intestines and is eliminated through the stool.

Support the estrogen detoxification process naturally with new advanced delivery liposomal technology. Liposomes are microscopic fat-soluble conduits that deliver targeted nutrition to our bloodstream. Because the nutrients are packaged in liposomes, they bypass gastric juices and maximise absorption directly into the bloodstream. As the liposomes are in liquid form, just a once daily health drink may be all that is needed to support hormonal balance.

SKU: Estro Detox Ultra Category:
  • Non-GMO tested ingredients
  • Gluten-free
  • Vegan
  • Dairy-free
  • Non-soy, pure sunflower phosphatidylcholine
  • Complex Irradiation: None (raw materials or finished product)
  • Supports both Phase l and Phase ll Liver detoxification 

A first for New Zealand, non-gluten, non-GMO, vegan, LipoRevolution™ Estro Detox Ultra, an easy to take dietary supplement supporting both Phase l and Phase ll Liver detoxification.

Our Liposomal Estro Detox Ultra contains a complex variety of natural ingredients that are found to support hormone balance for Men and Women with advanced delivery liquid liposomal technology, working harmoniously to balance your endocrine system.

Selenium is a nutrient that is prominently deficient in New Zealand soil and so in turn our produce is deficient in this nutrient, Selenium is important due to its critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection [1]. Selenium and female reproductive system have been closely linked; Selenium is an essential nutrient of fundamental importance in human biology [2]. Selenium deficiency implicated in Selenium miscarriage and infertility, in one trial, 100% of infertile women achieved pregnancy after selenium supplementation [3].

Pyridoxal 5’-Phosphate (P-5-P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions and can be directly utilized by the body without conversion. P-5-P is simply a more efficient form of pyridoxine and avoids the hepatic conversion processes needed to create the active enzyme form. This would likely be beneficial for those with impaired liver function. Ultimately, the case for P5P comes down to it being a bio-optimized form of Vitamin B6 that our body can put to work immediately. Using P-5-P has been linked to reduced inflammation [4], boosted immune response [5], supporting positive mood and relaxation [6], promotion of healthy red blood cell formation [4], and increased plasma magnesium [7]. Researchers have found that women who take a combination of Magnesium and activated B6 vitamins experienced reduced premenstrual stress symptoms, these results were significantly improved in comparison to placebo groups [8][9][10].

Zinc is a trace element that is necessary for a healthy immune system, a lack of Zinc can make a person more susceptible to disease and illness; this is due to its role in activating T lymphocytes (T cells) which control and regulate immune responses and attack infected or cancerous cells [11]. Only a small amount of Zinc is required to reap the benefits as it is responsible for a large variety of functions in the human body and helps stimulate the activity of at least 100 different enzymes [12].

Calcium D-glucarate is the calcium salt of D-glucaric acid, oral supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification [13]. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers [14][15]. Other potential clinical applications of oral calcium D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent, studies have shown that ingesting calcium D-glucarate lowers serum estrogen levels, because many breast cancers are estrogen-dependent, calcium D-glucarate’s ability to affect estrogen and other hormone levels has led to Phase I clinical trials at several major cancer centers in the United States [16].

Taurine is a conditional essential amino acid, naturally synthesized within the body in small amounts and found abundantly within the brain, muscles, retinas, heart and blood cells [17]. It serves as an essential building block for certain proteins and processes such as bile salt synthesis (which is essential in liver detoxification), and without it must be attained by additional supplementation [18][19][20]

Methionine is an amino acid that is used to prevent liver damage in acetaminophen (Tylenol) poisoning. Other proven uses for methionine include, increasing the acidity of urine, treating liver disorders, and improving wound healing. In a study by James D. Finkelstein it was found that methionine has a proven role in liver metabolism aiding in the methylation cycle [21]

Chasteberry or Vitex Agnus-Castus is a popular herbal supplement used to treat a variety of ailments, it is most popularly used to treat PMS and menopausal symptoms. Researchers believe that chasteberry works by decreasing levels of the hormone prolactin, this helps rebalance other hormones, including estrogen and progesterone — thus reducing PMS symptoms [22] [23] [24] [25].

Maca root – Maca root powder from the Maca plant (Lepidium meyenii), it is also sometimes referred to as Peruvian ginseng. Maca has been widely used to enhance fertility and improve sex drive, studies suggest that after a minimum of 6 weeks on Maca root powder an improvement in sex drive and sperm quality can be expected [26][27]. One review of four studies in menopausal women found that Maca helped alleviate menopausal symptoms, including hot flashes and interrupted sleep [28]. Additionally, Maca root has been proven to improve mood and reduce anxiety [29][30][31]

Glucuronolactone is a small molecule that contributes to the structure of connective tissues, it is an essential precursor of ascorbic acid (Vitamin C) synthesis and detoxicant. Glucuronolactone combines with toxic substances and converts them into water-soluble conjugates that can be excreted in urine, it may have hepatoprotective effects in this capacity meaning that it can function to protect and maintain a healthy liver [32].

Glycine is one of three amino acids that your body uses to make glutathione, a powerful antioxidant that assists to protect your cells against oxidative damage caused by free radicals, which are thought to underlie many diseases [33]. Without enough glycine, your body produces less glutathione, which could negatively affect how your body handles oxidative stress over time. In addition, because glutathione levels naturally decline with age, ensuring that you get enough glycine as you get older may benefit your health [34][35].

Glutathione is an amino acid with strong antioxidant properties produced naturally by the liver, it plays key roles in metabolism and it has been suggested that glutathione could help treat nonalcoholic fatty liver disease due to its antioxidant properties and potential to detoxify, however more research is required [36].

Turmeric contains curcuminoids, the most important of which is curcumin an active ingredient within LipoRevolutionTM Estro Detox Ultra. Curcumin is the main active ingredient in turmeric, it has powerful anti-inflammatory effects and is a very strong antioxidant [37][38][39]. It blocks NF-kB, a molecule that travels into the nuclei of your cells and turns on genes related to inflammation, NF-kB is believed to play a major role in many chronic diseases [40][41].

N-acetyl cysteine (NAC) is a supplement form of cysteine, cysteine is a semi-essential amino acid. NAC is valued primarily for its role in antioxidant production, along with two other amino acids — glutamine and glycine — NAC is needed to make and replenish glutathione. Glutathione is one of the body’s most important antioxidants, which helps neutralize free radicals that can damage cells and tissues in your body. Due to its anti-inflammatory and detoxification features NAC is an essential amino acid that has been widely linked to supporting liver health and function [42][43][44].

References:

  1. Sunde RA. Selenium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2012:225-37
  2. Schwarz K, Foltz CM. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am Chem Soc 1957;79(12):3292–3293.
  3. Howard J, Davies S, Hunnisett A. Red cell magnesium and glutathione peroxidase in infertile women – effects of oral supplementation with magnesium and selenium. Magnes Res 1994;7:49-57.
  4. Huang, S.-C., Wei, J. C.-C., Wu, D. J., & Huang, Y.-C. (2010). Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. European Journal of Clinical Nutrition64(9), 1007–1013. doi: 10.1038/ejcn.2010.107
  5. Cheng, C.-H., Chang, S.-J., Lee, B.-J., Lin, K.-L., & Huang, Y.-C. (2006). Vitamin B6 supplementation increases immune responses in critically ill patients. European Journal of Clinical Nutrition60(10), 1207–1213. doi: 10.1038/sj.ejcn.1602439
  6. Garcia-Lopez, R. (2012). New therapeutic approach to Tourette Syndrome in children based on a study of the effectiveness and safety of magnesium and vitamin B6. Http://Isrctn.org/>. doi: 10.1186/isrctn41082378
  7. Lumeng, L., Lui, A., & Li, T. K. (1980). Plasma content of B6 vitamers and its relationship to hepatic vitamin B6 metabolism. Journal of Clinical Investigation66(4), 688–695. doi: 10.1172/jci109906
  8. Iasco, S., Castro, A., & Atallah, A. (1999). Vitamin B6 for premenstrual syndrome. Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.cd001397
  9. Ebrahimi, E., Khayati Motlagh, S., Nemati, S., & Tavakoli, Z. (2012, November 22). Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161081/
  10. Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010, December). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208934/
  11. Kaltenberg, J., Plum, L. M., Ober-Blöbaum, J. L., Hönscheid, A., Rink, L., & Haase, H. (2010). Zinc signals promote IL-2-dependent proliferation of T cells. European Journal of Immunology40(5), 1496–1503. doi: 10.1002/eji.200939574
  12. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77(3):491-498
  13. Oredipe OA, Barth RF, Hanausek-Walaszek M, et al. Effects of an inhibitor of beta-glucuronidase on hepatocarcinogenesis. Proc Am Assoc Cancer Res 1987;28:156.
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  15. Heerdt, AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-105
  16. Walaszek Z, Hanausek-Walaszek M, Minto JP, Webb TE. Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis 1986;7:1463-1466.
  17. Ripps, H., & Shen, W. (2012). Review: taurine: a “very essential” amino acid. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23170060
  18. (n.d.). Taurine: Uses, Side Effects, Interactions, Dosage, and Warning. Retrieved from https://www.webmd.com/vitamins/ai/ingredientmono-1024/taurine
  19. Mawer, R. (2018, November 27). What Is Taurine? Benefits, Side Effects and More. Retrieved from https://www.healthline.com/nutrition/what-is-taurine#functions
  20. Yamori, Y., Taguchi, T., Hamada, A., Kunimasa, K., Mori, H., & Mori, M. (2010). Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. Journal of Biomedical Science17(Suppl 1). doi: 10.1186/1423-0127-17-s1-s6
  21. Finkelstein, J. D. (1974). Methionine metabolism in mammals: The biochemical basis for homocystinuria. Metabolism23(4), 387–398. doi: 10.1016/0026-0495(74)90057-2
  22. Die, M. V., Burger, H., Teede, H., & Bone, K. (2012). Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials. Planta Medica79(07), 562–575. doi: 10.1055/s-0032-1327831
  23. Arentz, S., Abbott, J. A., Smith, C. A., & Bensoussan, A. (2014). Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complementary and Alternative Medicine14(1). doi: 10.1186/1472-6882-14-511
  24. Tesch, B. J. (2002). Herbs commonly used by women: An evidence-based review. Disease-a-Month48(10), 671–696. doi: 10.1016/s0011-5029(02)90011-8
  25. Chopin Lucks, B. (2003, August). Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/12852933
  26. Gonzales, G. F., Cordova, A., Vega, K., Chung, A., Villena, A., Gonez, C., & Castillo, S. (2002). Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia34(6), 367–372. doi: 10.1046/j.1439-0272.2002.00519.x
  27. Lee, M. S., Lee, H. W., You, S., & Ha, K.-T. (2016). The use of maca ( Lepidium meyenii ) to improve semen quality: A systematic review. Maturitas92, 64–69. doi: 10.1016/j.maturitas.2016.07.013
  28. Lee, M. S., Shin, B.-C., Yang, E. J., Lim, H.-J., & Ernst, E. (2011). Maca (Lepidium meyenii) for treatment of menopausal symptoms: A systematic review. Maturitas70(3), 227–233. doi: 10.1016/j.maturitas.2011.07.017
  29. Brooks, N. A., Wilcox, G., Walker, K. Z., Ashton, J. F., Cox, M. B., & Stojanovska, L. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause15(6), 1157–1162. doi: 10.1097/gme.0b013e3181732953
  30. Stojanovska, L., Law, C., Lai, B., Chung, T., Nelson, K., Day, S., … Haines, C. (2014). Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric18(1), 69–78. doi: 10.3109/13697137.2014.929649
  31. Dording, C. M., Fisher, L., Papakostas, G., Farabaugh, A., Sonawalla, S., Fava, M., & Mischoulon, D. (2008). A Double-Blind, Randomized, Pilot Dose-Finding Study of Maca Root (L. Meyenii) for the Management of SSRI-Induced Sexual Dysfunction. CNS Neuroscience & Therapeutics14(3), 182–191. doi: 10.1111/j.1755-5949.2008.00052.x
  32. (2015, February 11). Ameliorative effects of D-glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S1756464615000304
  33. Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., … Abete, P. (2018, April 26). Oxidative stress, aging, and diseases. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/
  34. Persaud, C., Forrester, T., & Jackson, A. A. (1996, November). Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8914954
  35. McCarty, M. F., O’Keefe, J. H., & DiNicolantonio, J. J. (2018). Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29559876
  36. Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC Gastroenterology17(1). doi: 10.1186/s12876-017-0652-3
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Supplement Facts

8 fl. oz/240ml per bottle. Serving Size: 10 ml. Servings per Bottle: 30

Per Serving

%DV

Vitamin A (as beta carotene 50%, vitamin A, palmitate) 5000 iu 100
PC liposomal complex (from non-GMO
sunflower oil extract)
 750mg *
Pyridoxal 5′ phosphate (P-5-P activated B6) 17mg 1000
Zinc (as zinc picolinate) 10mg 67
Selenium (as selenomethionine) 200mcg 286
Calcium (as calcium d-glucarate) 36mg 4
Estro Detox Ultra Formula:
Calcium d-glucarate, L-Taurine, L-Methionine, Chaste tree berry extract, Maca root extract,
Glucuronolactone, L-Glycine, L-Glutathione, Turmeric root extract (curcuminoids 95%),
N-Acetyl Cysteine
1300mg *

Other Ingredients: Purified water, natural flavours (fruits, berries), organic Glycerin, Potato starch (non-gmo), Steviol Glycosides (from Stevia leaf extract), xanthan gum, acacia gum, potassium sorbate.
Directions: 8 millilitres daily or as directed by your physician. Mix into one ounce juice as a palatable way to ingest. Gently shake before using. Keep refrigerated and use within 45 days of opening. Tested non-gmo. Natural flavours are fruit and berry extracts and contain no msg.

* %DV (Daily Value) not established