Vitamin B12 (in the form of Methylcobalamin) supports brain and nerve health; it is called “neurologically active.” Your liver must convert regular B12 (cyanocobalamin) into methylcobalamin. Some people have difficulty converting inactive cyanocobalamin into active methylcobalamin. We believe it’s best to err on the cautious side and provide activated/broken down B12 in the most bioavailable form possible.
Most B12 supplements are broken down by stomach acid prior to being absorbed into the bloodstream and carried to cells, whereas liposomal B12 allows the active B12 vitamin to be encased in a protective fatty liposome to provide a barrier against stomach acids, so more nutrients get delivered where you need them: in your cells.
Methylfolate, otherwise known as 5 MTHF, is the active form of folate, rather than the standard alternative nutrient folic acid or synthetic vitamin B9. Up to 1 in 3 individuals carries a genetic mutation called MTHFR in which they have difficulty breaking down folic acid into folate, which carries risks of elevated homocysteine-related to heart concerns as well as neurotransmitter (brain chemical messenger) issues. We believe it’s best to err on the side of caution and provide activated/broken down folate (methylated folate) in its most bioavailable form possible.
Liposomal B12/Methylfolate may benefit the following:
- tingling or burning prickling sensations in the legs and hands
- brain function1
- energy levels if deficient in B12
- mood health2
- digestive health
- healthy fertility, pregnancy and lactation3
- suitable for all ages, but particularly indicated for those experiencing fatigue, vegetarians, those taking oral contraceptives or diabetic medications, the elderly and those with digestive concerns.
- Vitamin B12, folic acid, and the nervous system. Reynolds E. Lancet Neurol. 2006 Nov;5(11):949-60.
- Vitamin B12 supplementation in treating major depressive disorder: a randomised controlled trial. Syed EU, Wasay M, Awan S. Open Neurol J.2013 Nov 15;7:44-8. doi: 10.2174/1874205X01307010044. eCollection 2013.
- Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomised clinical trial in Bangladesh. Siddiqua TJ, Ahmad SM, Ahsan KB, Rashid M, Roy A, Rahman SM, Shahab-Ferdows S, Hampel D, Ahmed T, Allen LH, Raqib R. Eur J Nutr. 2016 Feb;55(1):281-93. doi: 10.1007/s00394-015-0845-x. Epub 2015 Feb 4.
- Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. Yamashiki M, Nishimura A, Kosaka Y. J Clin Lab Immunol. 1992;37(4):173-82.